Graphene–NHC–iridium hybrid catalysts built through –OH covalent linkage

Metal–organic and covalent organic frameworks as single-site catalysts

Heterogeneous single-site catalysts consist of isolated, well-defined, active sites that are spatially separated in a given solid and, ideally, structurally identical. In this review, the potential of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) as platforms for the development of heterogeneous single-site catalysts is reviewed thoroughly. In the first part of this art...

CovalentDock: Automated covalent docking with parameterized covalent linkage energy estimation and molecular geometry constraints

Covalent linkage formation is a very important mechanism for many covalent drugs to work. However, partly due to the limitations of proper computational tools for covalent docking, most covalent drugs are not discovered systematically. In this article, we present a new covalent docking package, the CovalentDock, built on the top of the source code of Autodock. We developed an empirical model of...

Covalent linkage of polyamines to peptidoglycan in Anaerovibrio lipolytica.

Spermidine and cadaverine were found to be constituents of the cell wall peptidoglycan of Anaerovibrio lipolytica, a strictly anaerobic bacterium. The peptidoglycan was degraded with the N-acetylmuramyl-L-alanine amidase and endopeptidase into two peptide fragments, peptide I and peptide II, at a molar ratio of 4:1. Peptides I and II were identified as L-alanine-D-glutamic acid(alphacadaverine)...

Polyphosphazene Microcapsules Fabricated through Covalent Assembly.

Hollow polyphosphazene microcapsules have been fabricated by the covalent layer-by-layer assembly of polydichlorophosphazene (PDCP) and hexamethylenediamine (HDA) on aminosilanized silica particles, followed by core removal in a HF/NH(4) F solution. The hollow and intact microcapsules in both wet and dry states have been characterized by transmission electron microscopy and confocal laser scann...

Improving Healthcare through Built Environment Infrastructure